Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDM4 All Species: 13.64
Human Site: S146 Identified Species: 33.33
UniProt: O15151 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15151 NP_002384.2 490 54864 S146 S A E E S S T S R K R T T E D
Chimpanzee Pan troglodytes XP_514127 490 54873 S146 S A E E S S T S R K R T T E D
Rhesus Macaque Macaca mulatta XP_001097583 479 53952 S141 S T E E S S T S R K R T T E D
Dog Lupus familis XP_536098 519 58173 S173 S A E E S S S S R K R M E E G
Cat Felis silvestris
Mouse Mus musculus O35618 489 54974 P146 G A T E Y S N P R K R T E E E
Rat Rattus norvegicus Q5XIN1 490 55202 P147 G A T E C S N P R K R T E E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507004 516 57467 T174 S A S P R K R T E E G D V A V
Chicken Gallus gallus XP_417957 481 54617 G152 G S D T V I M G D E S N A S A
Frog Xenopus laevis Q7ZYI3 475 53387 K147 T E V T D V I K R N D C V S S
Zebra Danio Brachydanio rerio Q7ZUW7 496 55223 L143 S I N S A Q P L I A G S S S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 92.8 88.8 N.A. 84 84.2 N.A. 68.5 59.7 47.1 47.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.8 94.4 90.7 N.A. 90.8 90.1 N.A. 78.6 73 65.9 62.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 73.3 N.A. 53.3 60 N.A. 13.3 0 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 80 N.A. 60 60 N.A. 26.6 20 13.3 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 60 0 0 10 0 0 0 0 10 0 0 10 10 10 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 0 0 10 0 10 0 0 0 10 0 10 10 0 0 40 % D
% Glu: 0 10 40 60 0 0 0 0 10 20 0 0 30 60 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 30 0 0 0 0 0 0 10 0 0 20 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 0 10 10 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 10 0 10 0 60 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 10 0 0 0 20 0 0 10 0 10 0 0 0 % N
% Pro: 0 0 0 10 0 0 10 20 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 0 10 0 70 0 60 0 0 0 0 % R
% Ser: 60 10 10 10 40 60 10 40 0 0 10 10 10 30 10 % S
% Thr: 10 10 20 20 0 0 30 10 0 0 0 50 30 0 10 % T
% Val: 0 0 10 0 10 10 0 0 0 0 0 0 20 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _